Instruments
NMR Spectrometer
Also Known As Nuclear Magnetic Resonance Spectrometer
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An analytical instrument that exploits nuclear magnetic resonance, the absorption and re-emission of radiofrequency energy by atomic nuclei with nonzero spin (commonly hydrogen-1 or carbon-13) placed in a strong external magnetic field, to determine the structure, purity and molecular environment of a sample. It grew out of Isidor Rabi's 1938 molecular-beam measurements of nuclear magnetic moments and the independent 1945 to 1946 discoveries of nuclear induction (Felix Bloch, Stanford) and nuclear magnetic resonance absorption in bulk matter (Edward Purcell, Harvard), and became one of the principal tools of structural chemistry and, in its magnetic-resonance-imaging (MRI) form, of medical diagnosis.
Facts
Invented YearBloch (Stanford) and Purcell (Harvard) independently detected nuclear magnetic resonance in bulk matter within months of each other, Purcell first in December 1945, both published in Physical Review in 1946; Rabi had already demonstrated the underlying molecular-beam magnetic resonance method in 1938. MeasuresThe chemical structure, purity and molecular environment of a sample, read through the resonance frequencies of its atomic nuclei. 1 Operating PrincipleNuclei with nonzero spin placed in a strong magnetic field precess at a frequency, the Larmor frequency, proportional to the field strength. A radiofrequency pulse tips the nuclear spins out of alignment, and the signal they emit while relaxing back into alignment, the free induction decay, is Fourier transformed to yield a spectrum whose peak positions and splittings reveal the chemical environment of each nucleus. 1 ResolutionSourced to the subject's own accountHigh-resolution instruments shim the magnetic field to parts-per-billion homogeneity over a volume of a few cubic centimeters 2 Operating RangeSourced to the subject's own accountRoughly 4 to 900 MHz in the radio-frequency region, depending on the nucleus and magnet field strength (900 MHz for protons in a 21-tesla field) 2 Learn More
Six Weeks Apart
This article records tradition as it has been passed down and reported. Its sources are not yet part of the atlas's verified catalogue.
For most of 1945, two American physics groups worked toward the same discovery without knowing about each other. At Harvard, Edward Purcell, fresh off wartime radar research, reasoned that if a sample of solid paraffin were placed in a magnetic field and bathed in radio waves of just the right frequency, its hydrogen nuclei should absorb energy in a way a receiver could detect. On 15 December 1945 his team measured exactly that. Three hundred kilometers away at Stanford, Felix Bloch had been approaching the same physics from the opposite direction, asking not what the nuclei would absorb but what signal they would induce in a nearby coil as their spins realigned, a method he called nuclear induction. His team confirmed it in January 1946. Neither group knew the other was close until word reached them through the physics grapevine that spring, and the two papers, describing what was recognizably the same phenomenon reached by two different routes, appeared in the Physical Review within weeks of each other. Bloch and Purcell shared the 1952 Nobel Prize in Physics for discoveries that, within a generation, gave chemists a routine way to read the structure of a molecule from the inside, and gave medicine, decades later, the imaging technique now known as MRI.
Cross-Tradition Connections
Invented By
Independently detected NMR absorption in solid paraffin at Harvard in December 1945.
Independently developed nuclear induction, detecting NMR in bulk matter, at Stanford in early 1946.
Rabi 1938 molecular-beam magnetic resonance method discovered nuclear magnetic resonance itself and supplied the physical principle Bloch and Purcell later built into the bulk-matter NMR spectrometer.
Used In
NMR spectroscopy is a principal technique for determining protein and nucleic-acid structure in solution.
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