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Instruments

NMR Spectrometer

Also Known As Nuclear Magnetic Resonance Spectrometer

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An analytical instrument that exploits nuclear magnetic resonance, the absorption and re-emission of radiofrequency energy by atomic nuclei with nonzero spin (commonly hydrogen-1 or carbon-13) placed in a strong external magnetic field, to determine the structure, purity and molecular environment of a sample. It grew out of Isidor Rabi's 1938 molecular-beam measurements of nuclear magnetic moments and the independent 1945 to 1946 discoveries of nuclear induction (Felix Bloch, Stanford) and nuclear magnetic resonance absorption in bulk matter (Edward Purcell, Harvard), and became one of the principal tools of structural chemistry and, in its magnetic-resonance-imaging (MRI) form, of medical diagnosis.

Facts
Invented Year
1946 1
Bloch (Stanford) and Purcell (Harvard) independently detected nuclear magnetic resonance in bulk matter within months of each other, Purcell first in December 1945, both published in Physical Review in 1946; Rabi had already demonstrated the underlying molecular-beam magnetic resonance method in 1938.
Measures
The chemical structure, purity and molecular environment of a sample, read through the resonance frequencies of its atomic nuclei. 1
Operating Principle
Nuclei with nonzero spin placed in a strong magnetic field precess at a frequency, the Larmor frequency, proportional to the field strength. A radiofrequency pulse tips the nuclear spins out of alignment, and the signal they emit while relaxing back into alignment, the free induction decay, is Fourier transformed to yield a spectrum whose peak positions and splittings reveal the chemical environment of each nucleus. 1
ResolutionSourced to the subject's own account
High-resolution instruments shim the magnetic field to parts-per-billion homogeneity over a volume of a few cubic centimeters 2
Operating RangeSourced to the subject's own account
Roughly 4 to 900 MHz in the radio-frequency region, depending on the nucleus and magnet field strength (900 MHz for protons in a 21-tesla field) 2
Learn More
Six Weeks Apart

This article records tradition as it has been passed down and reported. Its sources are not yet part of the atlas's verified catalogue.

For most of 1945, two American physics groups worked toward the same discovery without knowing about each other. At Harvard, Edward Purcell, fresh off wartime radar research, reasoned that if a sample of solid paraffin were placed in a magnetic field and bathed in radio waves of just the right frequency, its hydrogen nuclei should absorb energy in a way a receiver could detect. On 15 December 1945 his team measured exactly that. Three hundred kilometers away at Stanford, Felix Bloch had been approaching the same physics from the opposite direction, asking not what the nuclei would absorb but what signal they would induce in a nearby coil as their spins realigned, a method he called nuclear induction. His team confirmed it in January 1946. Neither group knew the other was close until word reached them through the physics grapevine that spring, and the two papers, describing what was recognizably the same phenomenon reached by two different routes, appeared in the Physical Review within weeks of each other. Bloch and Purcell shared the 1952 Nobel Prize in Physics for discoveries that, within a generation, gave chemists a routine way to read the structure of a molecule from the inside, and gave medicine, decades later, the imaging technique now known as MRI.

Cross-Tradition Connections

Invented By

Independently detected NMR absorption in solid paraffin at Harvard in December 1945.

Independently developed nuclear induction, detecting NMR in bulk matter, at Stanford in early 1946.

Isidor Isaac Rabi, Scientists

Rabi 1938 molecular-beam magnetic resonance method discovered nuclear magnetic resonance itself and supplied the physical principle Bloch and Purcell later built into the bulk-matter NMR spectrometer.

Used In

Biochemistry, Disciplines

NMR spectroscopy is a principal technique for determining protein and nucleic-acid structure in solution.

In the Other Atlases
Sources
1. Nuclear Magnetic Resonance Spectroscopy (Wikipedia)
WikipediaLead section
Quote, Lead section
Nuclear magnetic resonance spectroscopy, commonly known as NMR spectroscopy or magnetic resonance spectroscopy (MRS), is a spectroscopic technique based on re-orientation of atomic nuclei with non-zero nuclear spins in an external magnetic field.
View the Source
1. Nuclear Magnetic Resonance Spectroscopy (Wikipedia)
WikipediaUsed In: ChemistryView the Source
1. Nuclear Magnetic Resonance Spectroscopy (Wikipedia)
WikipediaUsed In: BiochemistryView the Source
1. Nuclear Magnetic Resonance Spectroscopy (Wikipedia)
WikipediaUsed In: PhysicsView the Source
2. NMR Spectrometer (Wikipedia)
WikipediaIntroduction / Resonant frequency section
Quote, Introduction / Resonant frequency section
absorption of electromagnetic radiation in the radio frequency region from roughly 4 to 900 MHz
View the Source
2. NMR Spectrometer (Wikipedia)
WikipediaShim and lock section
Quote, Shim and lock section
High-resolution NMR spectrometers use shims to adjust the homogeneity of the magnetic field to parts per billion (ppb) in a volume of a few cubic centimeters.
View the Source
Isidor Isaac Rabi, Biographical (Nobel Prize)
NobelPrize.orgInvented By: Isidor Isaac RabiView the Source
Felix Bloch, Biographical (Nobel Prize)
NobelPrize.orgInvented By: Felix BlochView the Source
Edward M. Purcell, Biographical (Nobel Prize)
NobelPrize.orgInvented By: Edward Mills PurcellView the Source
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